Freeze drying is being increasingly used in both formulation development and manufacturing of pharmaceuticals for poorly solubles, biopharmaceutical molecules and, more recently, biosimilars.
Another trend is the growth in the number of siRNA and antibodybased formulations. These compounds regularly require freeze drying, not because of the active itself but to maintain the integrity of the formulation or vehicle to target the siRNA in the body.
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http://pharmtech.findpharma.com/pharmtech/article/articleDetail.jsp?id=658093
Tags: antibody, biosimilars, lyophilisation, lyophilization, processing, trends