When you entrust your product to someone else you need to be sure that you have the best people for the job, with the experience, expertise and equipment to ensure the best possible outcome.
BTL have specialized in freeze drying since the very beginning in 1997. We have successfully freeze dried a wide variety of materials on behalf of our clients, at the last count over 700 different substances. Our track record is impressive not only because of the range of materials, each with their own challenges – chemicals, proteins, bacteria, nano-particles, polymers, high value food products, archaeological artefacts, but also the formulation formats that we routinely handle including liposomes, parenteral formulations and coatings. Our laboratory features a range of analytical equipment, including proprietary designs, that is used to build an accurate and comprehensive understanding of your product and its behavior.
The unique characteristics of each product type, formulation and customer requirements means that every project presents a unique set of challenges. When you entrust your project to BTL you benefit from our in depth knowledge and experience of what works and what does not. Our objective is to help you achieve your goals and assist you to develop an optimal process for your needs. We can advise you every step of the way on the journey from initial formulation strategy, process development, product characterisation, process optimisation scale up and trouble shooting.
In-depth characterisation of your product in terms of its key thermal temperatures and behaviour is the first step in product and process development. This information will provide the foundation for all further R&D, scale-up and QC.
Formulation Development combines in-depth product characterization with our extensive knowledge of excipients. A well-designed formulation will provide protection from the stresses of freeze drying, whilst also ensuring a thermal profile that is favourable for freeze drying.
A successful freeze drying cycle will provide reliable, safe processing in a timely and efficient manner. BTL’s cycle development services will tailor the freeze drying process to the requirements of your product and the capabilities of your equipment.
Apparently minor changes in formulation, container or equipment can affect the efficiency and efficacy of a freeze drying cycle. This service will ensure your processes are optimised for your requirements.
We offer small-scale processing runs to provide process testing, production flexibility, or fall-back capabilities.
LyoHealth Check is a complete freeze drying analysis / validation service, utilising an integrated suite of analytical methods to identify and quantify the key freeze drying parameters that are vital for successful process design and optimisation. BTL can then provide advice or assistance with formulation and process to rectify any problem areas.
LyoHealth Check can also be used to provide data for regulatory and validation requirements.
BTL has significant experience in collaboration with academia and industry and is always keen to explore new relationships which will progress the field of lyophilisation.
BTL provides a range of options in training in freeze drying technology.